![]() ![]() The stenosis was seen to be present as early as the sixteenth day of gestation, and occlusion was observed in 17-day-old animals. The serial sections demonstrated an occluded or extremely stenotic aqueduct of Sylvius in every hydrocephalic animal examined. Hydrocephalus was the only defect observed in the treated animals. Fetuses were excised from days 16 through 20, processed routinely, decalcified, if necessary, embedded in paraffin, serially sectioned, and stained. ![]() If the injection was not made, most animals resorbed their litters. The period of deficiency was terminated by an injection of 500 μg of folic acid in water. Wistar strain albino rats were fed a folic acid free diet with added folic acid antagonists (x-methyl folic acid and 9-methyl pteroylglutamic acid) for a 48-hour period beginning on day 8 and ending on day 10 of gestation.
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